On November 21, 2006, 19-year-old Jesse Ross was attending a Model United Nations conference in Chicago. Jesse called his parents to tell him he was having a great time. They would never hear or see their son again.

On the morning of May 3, 2017, 8-months-pregnant Akia Eggleston was excited to finally get out of her home to attend her baby shower. However, when the 22-year-old was hours late, loved ones rushed to her home to find Akia gone without a trace.

On September 20, 1988, Tara Calico left her home to go on a bike ride she took almost every morning. When she didn't return home, her mom anxiously drove along Tara's usual bike route, but never finds her. 30 years later, Tara is still missing.

27-year-old Ohio State University medical student, Brian Shaffer, fails to show up for a flight to Miami. Surveillance footage shows him leaving a bar the night before, but he's never seen again.

On January 27, 2017, 20-year-old Elaine Park goes to a movie with her boyfriend and then sleeps over at his apartment. At 6:00am the next morning, surveillance footage shows her leaving his apartment. She hasn't been seen since.

On a quest for personal enlightenment, Kristal Reisinger, a 29-year-old mother of one, heads out to take part in a drum circle in Crestone, Colorado on July 13, 2016. But as night turns into day, Kristal disappears, and she hasn't been seen since.

On May 1, 2017, 18-year-old Desirea Ferris spends the day hanging out with her sister and plans to celebrate her mom's birthday that night. She never makes it home and hasn't been heard from since.

On August 10, 2018, Matthew Weaver, Jr. goes out with a friend and after he drops her back off at home, heads for a drive through the Malibu canyons. He sends a mysterious text to her the next day and is never heard from again.

Twenty-three year-old Brandi Wells is a spirited young woman about to get a second chance in pursuing her lifelong goal. But, her dreams are cut short when police find her abandoned vehicle the morning after she goes out alone to a nightclub.

A locally adored and respected mother of three living in Colorado vanishes. Her community is shocked to learn she has been working as an adult escort. With a violent previous marriage, and another marriage before that, no one knows whom to blame.

25-year-old Amy St. Laurent vanishes one night while out on a date with an out of town friend. Suspicion soon falls on a suspected sexual predator, but detectives need to work around the clock to find a way to connect him to the grisly crime.

Michele Whitaker is vivacious, attractive, and out of control. Drinking heavily and fighting with her mother, she hitches a ride to a truck stop and disappears. Most think she is dead, but her family never gives up.

Lee Cutler is the universally loved high school senior who disappears after dropping off his best friend on a cool autumn morning. The search involves police officers across two states, underwater divers, and a nationwide watch.

Maura Murray goes missing after her car swerves off a dark and windy road over 140 miles away from her dorm. As the years pass, her family and friends refuse to give up their search to discover what happened to her that fateful February night.

Billy Smolinski is a hard working tough guy who suddenly disappears a week after discovering that his girlfriend is cheating on him. Although police don't suspect the woman, clues point their investigation in the direction of her now dead son.

A college student disappears after leaving her son with a childhood friend. Her car is found abandoned a week later across state lines. Soon after, a warrant for her arrest is issued on felony theft charges. Could she be on the run?