On November 21, 2006, 19-year-old Jesse Ross was attending a Model United Nations conference in Chicago. Jesse called his parents to tell him he was having a great time. They would never hear or see their son again.

On the morning of May 3, 2017, 8-months-pregnant Akia Eggleston was excited to finally get out of her home to attend her baby shower. However, when the 22-year-old was hours late, loved ones rushed to her home to find Akia gone without a trace.

On September 20, 1988, Tara Calico left her home to go on a bike ride she took almost every morning. When she didn't return home, her mom anxiously drove along Tara's usual bike route, but never finds her. 30 years later, Tara is still missing.

In 1976, the first of four children is abducted and murdered in the suburbs of Detroit. After more than 30 years the families of the four murdered children and Detroiters like J. Reuben Appelman are determined to find the Oakland County Child Killer.

Twenty-three year-old Brandi Wells is a spirited young woman about to get a second chance in pursuing her lifelong goal. But, her dreams are cut short when police find her abandoned vehicle the morning after she goes out alone to a nightclub.

A locally adored and respected mother of three living in Colorado vanishes. Her community is shocked to learn she has been working as an adult escort. With a violent previous marriage, and another marriage before that, no one knows whom to blame.

25-year-old Amy St. Laurent vanishes one night while out on a date with an out of town friend. Suspicion soon falls on a suspected sexual predator, but detectives need to work around the clock to find a way to connect him to the grisly crime.

Michele Whitaker is vivacious, attractive, and out of control. Drinking heavily and fighting with her mother, she hitches a ride to a truck stop and disappears. Most think she is dead, but her family never gives up.

Lee Cutler is the universally loved high school senior who disappears after dropping off his best friend on a cool autumn morning. The search involves police officers across two states, underwater divers, and a nationwide watch.

Maura Murray goes missing after her car swerves off a dark and windy road over 140 miles away from her dorm. As the years pass, her family and friends refuse to give up their search to discover what happened to her that fateful February night.

Billy Smolinski is a hard working tough guy who suddenly disappears a week after discovering that his girlfriend is cheating on him. Although police don't suspect the woman, clues point their investigation in the direction of her now dead son.

A college student disappears after leaving her son with a childhood friend. Her car is found abandoned a week later across state lines. Soon after, a warrant for her arrest is issued on felony theft charges. Could she be on the run?

As America's leading Atheist, Madalyn Murray O'Hair was also known as America's most hated woman. In 1995, when she inexplicably disappears along with two members of her family, and over a half-million dollars, rumors flew.

A Tampa Bay area realtor goes missing and investigators question her husband. Without evidence to make an arrest, investigators' case goes cold, while the husband leaves town with his girlfriend. Nine years later, the girlfriend helps solve the case.

John Spira is a beloved Chicago blues guitarist who disappears after leaving work one wintry evening. The intense search for the 45-year-old spans two years and commands the use of teams of investigators and state of the art equipment.

A former NBA star and his girlfriend enjoy sailing around the South Pacific until his estranged brother shows up. When the couple disappears and the brother shows up back in the U.S., the FBI investigates. Will they ever be found?