John Walsh profiles Juan Lazaro Abrego who is believed to have murdered his ex-girlfriend, a schoolteacher. Callahan Walsh investigates Derek Dean, a St. Louis man accused of shooting a pair of identical twins, killing one and wounding the other.

John Walsh tracks the story of convicted killer Glen Stark Chambers, who beat his young girlfriend to death and then escaped prison - twice. Then, Callahan investigates how Jesus Salazar avoids capture after allegedly committing murder 20 years ago.

John Walsh profiles John Blauvelt, a troubled U.S. Army vet who is accused of waging a lethal war against his young wife. Later, Callahan looks at Rudy Fernandez, whose teen romance with his high school sweetheart is believed to have turned deadly.

Alicia Osibin's neighbors trusted her, but John Walsh looks at whether Alicia may be responsible for her own mother's murder. Then, Callahan speaks with Andrea, alleged victim of Frederick McLean's abuse, who is still desperate for McLean's capture.

John Walsh investigates how Eric Jones, the son of a preacher, allegedly turned to murder. Later, Callahan Walsh tries to make sense of how a dispute over a dog could provoke Ricardo Villanueva Cordova to reportedly commit murder in broad daylight.

John Walsh explores the case of youthful con man Edgardo Perez, who allegedly preyed on older men until it turned deadly. Callahan travels to Boulder where teenage babysitter Chris Deininger confessed to abusing 29 kids in his care before fleeing.

When a costly mistake allows a criminal to escape justice, John steps in to help investigators in pursuit of felon Lester Eubanks. And Cal looks into the case of William Stanson, a supposed loving father to turned out to be and sexual predator.

Barbara Mackle, a promising co-ed and real estate heiress, is kidnapped and buried alive in a coffin-like "capsule." From Washington D.C. to Miami, local police and the FBI race to find the culprit before Barbara's time underground runs out.

On one terrible morning, 10-year-old Leona O'Loughlin doesn't show up for school while her detective father, Leo, falls violently ill. Investigators consider the chilling possibility that someone might be trying to eliminate the entire family.

Twenty-three year-old Brandi Wells is a spirited young woman about to get a second chance in pursuing her lifelong goal. But, her dreams are cut short when police find her abandoned vehicle the morning after she goes out alone to a nightclub.

A locally adored and respected mother of three living in Colorado vanishes. Her community is shocked to learn she has been working as an adult escort. With a violent previous marriage, and another marriage before that, no one knows whom to blame.

25-year-old Amy St. Laurent vanishes one night while out on a date with an out of town friend. Suspicion soon falls on a suspected sexual predator, but detectives need to work around the clock to find a way to connect him to the grisly crime.

Michele Whitaker is vivacious, attractive, and out of control. Drinking heavily and fighting with her mother, she hitches a ride to a truck stop and disappears. Most think she is dead, but her family never gives up.

Lee Cutler is the universally loved high school senior who disappears after dropping off his best friend on a cool autumn morning. The search involves police officers across two states, underwater divers, and a nationwide watch.

Maura Murray goes missing after her car swerves off a dark and windy road over 140 miles away from her dorm. As the years pass, her family and friends refuse to give up their search to discover what happened to her that fateful February night.

Billy Smolinski is a hard working tough guy who suddenly disappears a week after discovering that his girlfriend is cheating on him. Although police don't suspect the woman, clues point their investigation in the direction of her now dead son.