Police are shocked when Savannah local Milton Bradley is found brutally murdered. They soon discover he’s the victim of a ruthless killer who preys on gay men. The FBI must track this transient hustler and catch him before he strikes again.

When healthy patients in NJ hospitals die of mysterious causes doctors are baffled. An investigation reveals they were victims of a sinister poisoning spree. Officials hone in on a hospital employee with a questionable record and a troubled past.

Police rush to the home or Raman Salcido, a suspected spree killer whose marriage is crumbling. There they find Ramon’s wife dead and the couple’s three daughters missing. Can police track down Ramon and the girls before it’s too late?

Anna Hopkins tells police that her 23-year-old daughter has vanished after a night at a local bar. Patrons report that she left with an unidentified man. Hopkins takes matters into her own hands, staking out the bar in hopes that the man will return.

When Carol Hilley reveals that her mother Marie has been secretly injecting her with poison, Marie is arrested for attempted murder. After posting bail, Marie vanishes. Can police track down this manipulative killer before she strikes again?

A young man franticly tells police that he's escaped from the house of a torturous madman named Bob. Police storm the house and discover a torture chamber. Investigators suspect Bob of murder but must discover where he has buried the bodies.

When 23-year-old Laura Houghteling goes missing police suspect the family gardener, an eccentric man with a history of cross-dressing. Laura’s mother believes he’s innocent but when investigators search his storage shed they make a shocking discovery

When an intruder bursts into Melinda Aguilar’s apartment she fears the worst. But she miraculously frees herself and calls for help. When Police arrest the intruder and run his background they suspect he’s behind a vicious multi-state murder spree

When investigators find young women strangled along the I-5 freeway, they think they have a serial killer on their hands. But, when they discover distinctive cuts in the victims clothing they realize they’re facing someone far more sadistic.

When a Dallas medical examiner discovers both eyeballs have been removed from a recent homicide victim a routine murder enquiry quickly turns into a frantic manhunt to track down a ruthless and compulsive serial killer.

A hunter is on the loose in Ohio, stalking down human prey and murdering them in random acts of violence. With no apparent motive, Investigators conclude they’re after a savage madman driven only by the thrill of the hunt and his lust to kill.

Women are disappearing from Vancouver’s streets at an alarming rate. Are they leaving the area by choice? Or is something far more menacing going on? As Police investigate they discover that Canada’s most prolific serial killer is to blame.

When a Saint Louis news reporter covers a story on an unsolved murder he’s shocked to receive a map marking the location of a body. It triggers a hunt for more victims that leads cops down into a residential basement from their worst nightmares.

When LA Police find a driver’s license dumped in a trashcan they suspect a man wanted for the murder of a local teen has discarded it. But, as the net closes in on the killer the Police learn there’s more to this plot than they first had in mind.

Dr. Mark Weinberger vanished and his wife Michelle Kramer has no idea where he is. Weinberger's story is a twisted tale of greed and power that leaves Michelle in tears and an entire town in horror. He is America’s most-wanted "Runaway Doctor."