20-year old Bear Diaz has diabetes, leaving him weak and vulnerable. When he vanishes in the night with his TV, backpack and cash, investigators must consider foul play. Then Skylar Tosic disappears, leaving people wondering if the cases are linked.

Kortne Stouffer, 21, vanishes from her bed one night following a couple of scuffles with neighbors and friends. Investigators pursue various leads, but the young beauty is nowhere to be found, and her family clings to an endless hope.

When Macin Smith, 17, doesn't come home from school, his parents worry is he in danger? A note hidden in his wallet leaves his family troubled. And police attempt to piece together the puzzle, while his family vacillates between hope and despair.

A Bible-teaching mom takes a midnight walk and never comes home. But a mysterious note suggests frightening possibilities.

When recent college graduate Jennifer Kesse doesn't show up for work, her friends and family know something is wrong. Their worst fears are realized after her car is found empty and abandoned a mile from her apartment. Police immediately investigate the dozens of construction workers who are building Kesse's apartment complex at that time, however no clear suspect emerges. Almost a decade later, this mysterious case continues to baffle law enforcement and haunt her family.

Former Harlem Globetrotter Rico Harris is driving from LA to Seattle to move in with his fiancée, Jennifer Song. The 37-year old is in constant contact with Song and his mother from the road but, after he mentions a detour into the mountains, all communication ceases.

Brian Histand, a 25-year-old BMX rider, was last seen wandering a field in southern Phoenix. As family and friends search, they learn of Brian's disconcerting behavior in his final days. Have Brian's risky bike moves led to his state of confusion?

60-year-old stonemason, David Riemens, has one final meeting before driving to visit family. He never returns home, and his truck is found abandoned. Desperate to find him, investigators look for clues, but David has vanished into thin air.

37-year-old nurse Tammy Kingery, suffers a mysterious illness and is bed-ridden at home. One day, when her husband and children leave to run errands, they return to discover that Kingery has disappeared. The investigation will reveal dark secrets that lead to all kinds of theories about what happened to Tammy.

When 19-year-old college student Bryce Laspisa heads south to visit his parents in Orange County, CA, what should've been a quick five-hour drive down the freeway turns into a 20-hour expedition. Laspisa is in constant contact with his parents from the road, but he's behaving mysteriously. When his car is found crashed and abandoned in a remote desert park, investigators begin a desperate search for clues into Laspisa’s disappearance.

25-year-old artist Tiffany Daniels is a spontaneous free spirit, but when she doesn't return home from work for days, her brand new roommate grows alarmed. When her car is found abandoned in a beachside parking lot, it’s a desperate race against the clock for any sign of Tiffany.

Jessica Heeringa works the night shift at a gas station to help support her 3-year-old son and fiancé. One evening a customer arrives to find the store empty and the cash drawer left open, investigators find themselves in a race against time to locate the missing 25-year-old mom.

More mysteries are revealed in Kelly's disappearance when video footage of him at a gas station, hours before he disappeared, show him as his normal happy self.

Lauryn Garrett's parents talk about what kind of person she is as well as how her disappearance affected them.

Charli Scott was last seen on a treacherous road, her friends and family fear there's been an accident. But as pieces of evidence surface, the mystery heightens.

Investigator Gary Micco travels with Charli's step-father to check out the site where Chari's burnt out car is located, and all the clues don't seem to be adding up to finding Charli.

Tina McQuaig, a 27-year-old wife and mother, disappears one day after leaving work. Her car, found days later, leaves no clues -- only more questions.

Danice Day, a recovering drug addict has gone missing in Monte Vista, Colorado. Did the pressure of sobriety become too much, or has someone harmed her?

On January 9, 2002 Danice Day, a recovering drug addict, has gone missing in Monte Vista, Colorado. Just when family members start to give up hope, a new sheriff takes office and renews their faith that one-day they will have answers.

On November 25, 2006, Alicia “Mandy” Stokes leaves her Oakland, California apartment home to run errands and never returns home. After not seeing their daughter for years, her family is left to wonder what happened to Mandy?

When Mandy fails to return home one night, her brother -- and roommate -- figures she had other plans. A mother's concern sparks a search with a twist.

When Colleen Orsborn skips school to go to the beach, it seems the worst that can happen is a scolding from her parents. But a mother's worst fears are realized when Colleen never returns home.

Successful businessman and family man, Mike Williams, goes duck hunting on a Florida lake days before Christmas...He disappears. Some say alligators ate him but his mother isn't buying it. Is it foul play?

College freshman, Virginia "Ginni" Wood, drops out of contact with her mother while on a spring break road trip with her boyfriend and best friend. During the investigation it is discovered that three other children have also disappeared. Are the ...

On February 13, 2001, Pat Viola calls her mother to chat. Nothing about the phone call seems odd, but Pat is never heard from or seen again. Her family knows she would never abandon her children, so they suspect Pat was a victim of foul play.

Ginni Wood, a college freshman, drops out of contact with her mother while on a spring break road trip to visit her best friend Kelly. What happened to her?

Jamie Fraley vanished from her North Carolina apartment with no signs of foul play. Is her boyfriend's father involved in her disappearance?

Jamie Fraley vanished from her North Carolina apartment with no signs of foul play. Was her boyfriend's father involved in her disappearance?

In what friends describe as uncharacteristic behavior, Lily Aramburo left her fiancé's Miami condo at 2 a.m. without her 9-month old son and she never returned.

Twenty-four-year-old Lily Aramburo left her fiancé's Miami condo at 2 a.m., carrying only two bungee cords. Everyone knows that Lily would not have willingly left her 9-month old son behind, was there foul play involved in her disappearance?

When Terrance Williams goes missing, his family fears he may have been picked up for driving without a license. However they encounter an even deeper mystery when Terrance's vehicle turns up without Terrance inside.

Allison Jackson-Foy left a bar after drinks with a close friend and was never seen or heard from again. Her extended family says there is no way she would have left her daughters behind, but was she fed up with her stormy marriage?