20-year old Bear Diaz has diabetes, leaving him weak and vulnerable. When he vanishes in the night with his TV, backpack and cash, investigators must consider foul play. Then Skylar Tosic disappears, leaving people wondering if the cases are linked.

Kortne Stouffer, 21, vanishes from her bed one night following a couple of scuffles with neighbors and friends. Investigators pursue various leads, but the young beauty is nowhere to be found, and her family clings to an endless hope.

When Macin Smith, 17, doesn't come home from school, his parents worry is he in danger? A note hidden in his wallet leaves his family troubled. And police attempt to piece together the puzzle, while his family vacillates between hope and despair.

A Bible-teaching mom takes a midnight walk and never comes home. But a mysterious note suggests frightening possibilities.

When recent college graduate Jennifer Kesse doesn't show up for work, her friends and family know something is wrong. Their worst fears are realized after her car is found empty and abandoned a mile from her apartment. Police immediately investigate the dozens of construction workers who are building Kesse's apartment complex at that time, however no clear suspect emerges. Almost a decade later, this mysterious case continues to baffle law enforcement and haunt her family.

Former Harlem Globetrotter Rico Harris is driving from LA to Seattle to move in with his fiancée, Jennifer Song. The 37-year old is in constant contact with Song and his mother from the road but, after he mentions a detour into the mountains, all communication ceases.

Brian Histand, a 25-year-old BMX rider, was last seen wandering a field in southern Phoenix. As family and friends search, they learn of Brian's disconcerting behavior in his final days. Have Brian's risky bike moves led to his state of confusion?

60-year-old stonemason, David Riemens, has one final meeting before driving to visit family. He never returns home, and his truck is found abandoned. Desperate to find him, investigators look for clues, but David has vanished into thin air.

37-year-old nurse Tammy Kingery, suffers a mysterious illness and is bed-ridden at home. One day, when her husband and children leave to run errands, they return to discover that Kingery has disappeared. The investigation will reveal dark secrets that lead to all kinds of theories about what happened to Tammy.

When 19-year-old college student Bryce Laspisa heads south to visit his parents in Orange County, CA, what should've been a quick five-hour drive down the freeway turns into a 20-hour expedition. Laspisa is in constant contact with his parents from the road, but he's behaving mysteriously. When his car is found crashed and abandoned in a remote desert park, investigators begin a desperate search for clues into Laspisa’s disappearance.

25-year-old artist Tiffany Daniels is a spontaneous free spirit, but when she doesn't return home from work for days, her brand new roommate grows alarmed. When her car is found abandoned in a beachside parking lot, it’s a desperate race against the clock for any sign of Tiffany.

Jessica Heeringa works the night shift at a gas station to help support her 3-year-old son and fiancé. One evening a customer arrives to find the store empty and the cash drawer left open, investigators find themselves in a race against time to locate the missing 25-year-old mom.

More mysteries are revealed in Kelly's disappearance when video footage of him at a gas station, hours before he disappeared, show him as his normal happy self.

Lauryn Garrett's parents talk about what kind of person she is as well as how her disappearance affected them.

Charli Scott was last seen on a treacherous road, her friends and family fear there's been an accident. But as pieces of evidence surface, the mystery heightens.

Investigator Gary Micco travels with Charli's step-father to check out the site where Chari's burnt out car is located, and all the clues don't seem to be adding up to finding Charli.

After 3 days at the beach for Spring Break, 17 year-old Brittanee Drexel vanishes just moments after texting her boyfriend. When police track her cell phone to an isolated rural area, known for alligators and swamps, her family fears the worst.

Tara Grinstead, a 30-year-old teacher and former beauty queen, disappears without a trace on October 24, 2005. Five years later, Tara Grinstead's disappearance still hinges on finding a DNA match to the latex glove found outside her home.

17-year-old Kara Kopetsky doesn't come from school one day causing her parents to panic. When no clues arise on her whereabouts, it appears that she has vanished.

After doing laundry at a local Laundromat, 28 year-old Nicqui McCown disappears. When her vehicle is found abandoned in an apartment complex with the laundry still inside, detectives and her family are left to wonder what happened the day she van ...

After six months in the Mojave Desert, following the custody loss of her children in Texas, 30 year-old April Pitzer is ready to come clean and return home. Yet when her mother sends for her a week later, she is nowhere to be found.

While shopping for land in Oklahoma, Bobby and Sherilyn Jamison and their six-year-old daughter Madyson vanish into thin air. To this day, the family is still missing. Have you seen them?

The day they're supposed to meet with the accountant about some financial discrepancies, John and Elizabeth Calvert suddenly disappear. Further investigation points towards their accountant, but the case takes a shocking turn.

22-year-old Bradyn Fuksa goes missing with money and his parent's handgun. As authorities from a half-dozen states try to track him, Bradyn remains missing, leaving his truck behind.

Tanya Rider went missing after work one day but was found seven days later, all thanks to her cellphone. Tanya Rider is alive today.

June 6, 1992, hours after their graduation, Stacy McCall, Suzie Streeter and her mother Sherrill Levitt go missing without a trace. They are later dubbed, "The Springfield Three".

More than 15 years after the disappearance of "The Springfield Three", clues to their location may lie beneath a parking garage at Cox Hospital. Will investigators find the answers they need to bring the missing women home?

Rachel Cooke, a 19-year-old college student goes out for a jog and disappears. She has no known enemies and no reason to run away. At first her family believes Rachel will soon return, but when she isn't home in the morning, they know something h ...

19-year-old college student, Rachel Cooke, goes out for a jog and disappears. Years later, a new suspect offers a shocking story of abduction and murder.

Steven Koecher's car is found abandoned near Las Vegas and no one has heard from him in two days. This clean-cut journalist is not the type to go missing.

Steven Koecher's car is found abandoned near Las Vegas, and no one has heard from him in two days. He's a clean-cut, church-going young journalist, not the type to go missing. There are no signs of violence, and no leads.

Virginia Tech co-ed Morgan Harrington gets separated from her friends at the Metallica concert in VA and disappears without a trace. The only clue left behind is her purse found in the parking lot-its contents spilled.