Mother of three, Holly Cantrell, is seen on security video exiting the Oklahoma hospital where she works but never returns home. Police learn Holly was keeping secrets, and her loved ones wonder if those had anything to do with her disappearance.

When Michael VanZandt, a veteran and father of three, disappears one night in Hermosa Beach, Ca., police suspect a group of strangers may be involved. But his loved ones are haunted by suspicions about his thrill seeking when considering his fate.

Ali Lowizter vanishes after getting off the school bus. The investigation stalls for two years until a tip comes in claiming Ali could have been trafficked. A SWAT team busts a prostitution house, but will it bring 16-year-old Ali home?

Thirteen-year-old Tabitha Tuders vanishes walking to her bus stop in Nashville, TN. Police think she's a runaway but it appears that there are disturbing circumstances behind her disappearance, leaving her family desperately seeking the truth.

College sophomore Martin Roberts is a popular fraternity brother, suddenly he goes missing. The only clue he leaves: a cryptic note. Baffling secrets emerge. But two years later, his family remains desperate to know what has happened to him.

When 70-year-old retired firefighter Michael Chambers goes missing, a bloody crime scene in his garage quickly indicates foul play. But authorities begin to believe that the crime scene may have been staged and that Michael may have left on his own.

Nancy Moyer isn't home when her kids come back from visiting their dad. Police look into her background, and find a more complicated life than anyone knows. But when a random murder occurs nearby, the question becomes could the cases be connected?

27-year-old pregnant woman, Charli Scott, vanished in Maui. Her stunned family and community ban together to look for her. Last seen on a treacherous road, they fear there's been an accident. But as pieces of evidence surface, the mystery heightens.

On May 1, a free-spirited 23-year-old Lauryn Garrett from Sequim, WA vanishes after calling her father for a ride home. Lauryn's family embarks on a journey to find her and uncover startling clues linked to her past that may help solve the mystery.

In 2014, 23-year-old Christina Morris spent an evening out with friends in Plano, Texas but never returned home. A massive search involving police, volunteer searchers and even drones ensues but each new fact about the case brings more questions.

25-year-old Kelly Nash vanishes from his Georgia home one night without a trace. His loved ones are heartbroken but quickly mobilize an intense search. And then...surveillance video surfaces. But is the image on it Kelly? And can it help find him?

In 1976, the first of four children is abducted and murdered in the suburbs of Detroit. After more than 30 years the families of the four murdered children and Detroiters like J. Reuben Appelman are determined to find the Oakland County Child Killer.

Star Washington Redskins safety Sean Taylor is shot dead by an intruder in his Miami home. And when it comes to the rich and famous, it seems like everybody has a motive...

In North Carolina, a retired Vietnam veteran sells off a piece of his land to a young family. No one can predict the modern day Hatfield McCoy neighbor feud that will ensue and the midnight shootout that will end it.

The Phillips’ family moves to a quiet seafront town in Maine to escape a crime wave in Indiana. But their dream home comes with a not so dreamy ex-military neighbor. A barrage of gunfire between the houses one night shatters both families forever.

What do you do when you fear for your life and the person at the end of the 911 line is the one you need protecting from? Two Altadena families are unlucky enough to find out when an LAPD cop moves in next door.