Billy Smolinski is a hard working tough guy who suddenly disappears a week after discovering that his girlfriend is cheating on him. Although police don't suspect the woman, clues point their investigation in the direction of her now dead son.

A college student disappears after leaving her son with a childhood friend. Her car is found abandoned a week later across state lines. Soon after, a warrant for her arrest is issued on felony theft charges. Could she be on the run?

As America's leading Atheist, Madalyn Murray O'Hair was also known as America's most hated woman. In 1995, when she inexplicably disappears along with two members of her family, and over a half-million dollars, rumors flew.

A Tampa Bay area realtor goes missing and investigators question her husband. Without evidence to make an arrest, investigators' case goes cold, while the husband leaves town with his girlfriend. Nine years later, the girlfriend helps solve the case.

John Spira is a beloved Chicago blues guitarist who disappears after leaving work one wintry evening. The intense search for the 45-year-old spans two years and commands the use of teams of investigators and state of the art equipment.

A former NBA star and his girlfriend enjoy sailing around the South Pacific until his estranged brother shows up. When the couple disappears and the brother shows up back in the U.S., the FBI investigates. Will they ever be found?

The disappearance of attorney Royal Scoop Daniel paralyzes a mountain town in Colorado and monopolizes more than three law enforcement agencies. The case shocks everyone involved.

In 1976, the first of four children is abducted and murdered in the suburbs of Detroit. After more than 30 years the families of the four murdered children and Detroiters like J. Reuben Appelman are determined to find the Oakland County Child Killer.

Queens, NY, 1965. Two children are found dead. The cops are convinced the parents Eddie and Alice Crimmins are guilty. Even after two trials both condemning Alice, it will take years to unravel the mystery of who killed Eddie and Missy.

New York, NY, 1963. Two young women are brutally murdered in their Upper East Side apartment. If these girls aren’t safe, who is? The NYPD is under pressure to solve the high-profile case but make a tragic misstep while investigating.

West Palm Beach, FL, 1955. Esteemed Judge Curtis Chillingworth and his wife say goodbye to friends at a dinner party and are never seen again. Police unravel a tale of corruption and evil that leaves Florida in shock.

Denver, CO, 1955. United Airlines Flight 629 explodes in mid-air, killing everyone aboard. Crash investigators wonder if it was an accident at all. What follows is the discovery of the first-ever act of murder-by-airplane-bombing in the U.S.

Michigan, 1967-69. A series of young females from Michigan universities are murdered one by one. The young women of Southeastern Michigan are terrified and the police commence a massive hunt for the monster they call The Co-Ed Killer.

New York, NY, 1955. Ann and Billy Woodward are the darlings of New York society when tragedy strikes after a drunken dinner party. Billy lies in a pool of his own blood. Ann pulled the trigger by accident...or so she says.

San Diego police race to catch a killer with an unthinkable calling card.

A brutal double homicide shatters two families.