When 17-year-old Macin Smith doesn't come home from school, his parents worry is he in danger? A note in his wallet leaves his family troubled. And police attempt to piece together the puzzle, while his family vacillates between hope and despair.

Twenty-one year-old Kortne Stouffer vanishes from her bed one night following a couple of scuffles with neighbors and friends. Investigators pursue various leads, but the young beauty is nowhere to be found, and her family clings to an endless hope.

A beautiful young woman moves to the United States for a new opportunity, but in a mere matter of weeks, she vanishes without a trace. Kidnapping survivor, Elizabeth Smart, joins in the search to find her in this mystery where the clues are sparse.

20-year old Bear Diaz has diabetes, leaving him weak and vulnerable. When he vanishes in the night with his TV, backpack and cash, investigators must consider foul play. Then Skylar Tosic disappears, leaving people wondering if the cases are linked.

After a night at home watching movies, 18-year-old Zoe Campos cannot be found by her family the next morning. As investigators pore through the teen's Facebook account, they discover she did not turn in early as her loved ones originally thought.

On route to the airport, nineteen-year-old Katelin Akens makes an unexpected stop at a Virginia shopping mall...and vanishes. Police investigate her loved ones and start to suspect that someone close to Katelin may know more than they’re saying.

Eight-year-old Zachary Bernhardt disappears from his Florida home late at night. Suspicions swirl around his mom, but she denies any involvement and moves away. When another boy goes missing, new theories emerge.

A young man gets life-changing news and drops everything to start a new chapter. But when he never calls home again his family knows something is wrong. Police begin to investigate but encounter a tangled web of contradictory stories.

When 15-yr-old Kayla Berg isn't home after a night out, her loved ones believe she's staying with friends. But when six days pass and the aspiring gymnast is missing, the details of her last known whereabouts raise suspicion in a close-knit town.

A date night in Philadelphia becomes disturbing when a couple disappears. Their families unite to find them, but as desperation grows, finger pointing puts them at odds. Soon, the FBI takes over the investigation that is riddled with speculation.

19-year-old Angel Garcia disappears after riding his dirt bike around Hartford CT. Friends say Angel was chased by a mysterious SUV before he disappeared. Months Later, a possible sighting in a convenience store 15 miles from home. Could it be Angel?

Deanne Hastings, a 35-year-old Spokane mom, leaves a note that she’s running to the store, but she never returns. As detectives uncover more information about Deanne’s actions leading up to her disappearance, a slew of troubling theories emerge.

Ashley Summers is a fun-loving 14-year-old. When she vanishes on July 4th, her family is at a loss. The mystery deepens when the FBI connects her case to two other young women missing from her neighborhood. Ten years later, there's still no answer.

Logan Schiendelman vanishes, and authorities find his car abandoned. Multiple tips claim seeing Logan, but searches turn up nothing. With no evidence of foul play, questions surface and police are forced to examine his family's controversial past.

While on a Caribbean cruise, 23-year-old Amy Bradley vanishes from her family's cabin and is never seen again. Over a decades-long struggle, her family embarks on countless grueling searches, stopping at nothing, they say, to find their beloved Amy.

Stephanie Crane, aged 9, walks home from the local bowling alley-but never arrives. Early leads go nowhere. For years authorities don't find her or make an arrest. Now, they hope that advances in evidence testing may finally solve the mystery.