Maura Murray goes missing after her car swerves off a dark and windy road over 140 miles away from her dorm. As the years pass, her family and friends refuse to give up their search to discover what happened to her that fateful February night.

Billy Smolinski is a hard working tough guy who suddenly disappears a week after discovering that his girlfriend is cheating on him. Although police don't suspect the woman, clues point their investigation in the direction of her now dead son.

A college student disappears after leaving her son with a childhood friend. Her car is found abandoned a week later across state lines. Soon after, a warrant for her arrest is issued on felony theft charges. Could she be on the run?

As America's leading Atheist, Madalyn Murray O'Hair was also known as America's most hated woman. In 1995, when she inexplicably disappears along with two members of her family, and over a half-million dollars, rumors flew.

A Tampa Bay area realtor goes missing and investigators question her husband. Without evidence to make an arrest, investigators' case goes cold, while the husband leaves town with his girlfriend. Nine years later, the girlfriend helps solve the case.

John Spira is a beloved Chicago blues guitarist who disappears after leaving work one wintry evening. The intense search for the 45-year-old spans two years and commands the use of teams of investigators and state of the art equipment.

A former NBA star and his girlfriend enjoy sailing around the South Pacific until his estranged brother shows up. When the couple disappears and the brother shows up back in the U.S., the FBI investigates. Will they ever be found?

The disappearance of attorney Royal Scoop Daniel paralyzes a mountain town in Colorado and monopolizes more than three law enforcement agencies. The case shocks everyone involved.

In the early morning hours of March 31, 2017, 16-year-old Devin Bond got out of bed and walked out of his Murfreesboro, Tennessee, home. He was never seen nor heard from again.

At 2:30am on January 4, 2019, 22-year-old mother Savannah Spurlock called her mother to tell her she was leaving the bar where she had enjoyed a much-deserved night out. Savannah told her mother she'd be home soon, but she was never seen again.

On November 21, 2006, 19-year-old Jesse Ross was attending a Model United Nations conference in Chicago. Jesse called his parents to tell him he was having a great time. They would never hear or see their son again.

On the morning of May 3, 2017, 8-months-pregnant Akia Eggleston was excited to finally get out of her home to attend her baby shower. However, when the 22-year-old was hours late, loved ones rushed to her home to find Akia gone without a trace.

On September 20, 1988, Tara Calico left her home to go on a bike ride she took almost every morning. When she didn't return home, her mom anxiously drove along Tara's usual bike route, but never finds her. 30 years later, Tara is still missing.

In 1976, the first of four children is abducted and murdered in the suburbs of Detroit. After more than 30 years the families of the four murdered children and Detroiters like J. Reuben Appelman are determined to find the Oakland County Child Killer.

Queens, NY, 1965. Two children are found dead. The cops are convinced the parents Eddie and Alice Crimmins are guilty. Even after two trials both condemning Alice, it will take years to unravel the mystery of who killed Eddie and Missy.

New York, NY, 1963. Two young women are brutally murdered in their Upper East Side apartment. If these girls aren’t safe, who is? The NYPD is under pressure to solve the high-profile case but make a tragic misstep while investigating.