When a troubled South Carolina woman vanishes without a trace, family and authorities band together and receive the shock of a lifetime.

When a young single mom disappears from a road trip, authorities look to her salacious side business for clues.

An inseparable pair of teenage girls are untraceable after a devastating fire rocks their rural Oklahoma community.

An avid outdoorsman disappears on a secret adventure that's hidden in Arizona's notorious Superstitious Mountains.

A Kansas couple are stunned when their straight-laced son vanishes with the family handgun.

When a fiercely independent teen vanishes, authorities ponder whether she is a victim or a rebel without a cause.

A vivacious hairstylist and two high school seniors vanish without a trace just after their graduation party.

A soldier's wife holding a scandalous secret disappears right before her husband deploys for Afghanistan.

Authorities scrub the California/Mexico border in search of a missing 15-year-old girl who is enamored with a 20-year-old man.

Derrick answers questions about the ongoing Norris case, including how the team tracked down Joe Pelland, how he kept personal emotions out of the investigation, and who he believes is responsible for abducting and killing the 7-year-old girl.

Derrick tackles questions surrounding the Faith Hedgepeth case, including who he believes is a person of interest, the DNA found in the apartment, and the meaning behind the mysterious note. Kris catches up with Faith's father.

Homicide or suicide? Derrick and Kris disagree on what happened to Christopher Jenkins that fateful Halloween night. Kris and private investigator Chuck Loesch go head-to-head with their differing opinions on the case.

Several months after Derrick and Kris' investigation in Coronado, new developments emerge regarding the death of Rebecca Zahau. This leads the team to defend their original opinions, and seek insight from former LA Times reporter Tony Perry.

After investigating 5 murders that occurred near the shores of Honolulu, Derrick and Kris recount the difficulties faced in their pursuit to uncover a serial killer. Retired homicide detective Louis Souza speaks out on his experience with the case.

The conclusions reached in the Michelle O'Keefe case are revisited, while new questions are answered. Mike O'Keefe provides updates on his struggle to process the past eighteen years, and where he stands on what happened to his daughter.

After the death of her husband, Jason, Kelly Cochran meets Hobart Detective Jeremy Ogden. When she makes a strange remark toward Ogden, his suspicion is raised and he brings her in for questioning.