Life is good for 12 year-old Garrett Phillips, until he's brutally attacked while home alone. His killer jumps unseen from a window and investigators are left with a vexing mystery that rattles the otherwise peaceful village of Potsdam, New York.

In Southwest Florida, Terrance Williams, a young father, disappears. As his mother retraces his steps she uncovers something ominous: the last known person to see Terrance alive has a strange and disturbing connection to another missing man.

A young mother from Austin, Texas suddenly drops out of contact. Police believe she may be taking a break somewhere, possibly with a new man. But Julie’s family fears the worst.

In the fall of 2005, Becky Sue MacDonald, a loving mother of four, breaks up with her abusive boyfriend and moves in with a relative to make a fresh start. When she goes missing, some wonder if she's hiding from her ex, but others suspect foul play.

A mother walking with her children collapses in a Cincinnati Park, and is rushed to the hospital. But when her husband comes to fetch the kids, he tells police that one of them is missing. A massive hunt is launched for their 3-year-old foster child.

Epifanio Medina is a neighborhood fixture in Passaic, NJ - a retiree who seems beloved by all. So when his body is discovered over 100 miles away in a New York State nature preserve, detectives are stumped.

Police are serving a bench warrant on local cashier Debra Sundstrom when they hear shots ring out inside the house. They find her shot dead upstairs - just as the entire house suddenly starts going up in flames.

When 91-year-old Washington VIP Viola Drath is found dead on her bathroom floor in her tony Georgetown townhouse, it appears she?s simply the victim of a nasty fall.

When the murdered body of Miami pediatric nurse Beverly Jackson is discovered under the most shocking of circumstances, her family is devastated.

Hard-working family man Chris MacCallum disappears while on a camping trip deep in the forest along the border of California and Oregon.

Hard-working family man Chris MacCallum disappears while on a camping trip deep in the forest along the border of California and Oregon.

Elizabeth Shoaf was forced into Vinson Filyaw's rape dungeon for ten days until she managed to escape.

When a rape victim's eyewitness testimony helps put an innocent man in prison, he works to expose the real rapist from behind bars.

Dino Pantazes and his wife Clara do everything together. When Clara ends up dead, police try to find the culprit and end up looking close to home.

Could picking the wrong doctor in your practice lead you towards a trail of death?

Young Alicia Kozakiewicz slips out one New Year's Eve to meet a new friend she's met on the Internet. But he's no friend.

When the murdered body of Miami pediatric nurse Beverly Jackson is discovered under the most shocking of circumstances, her family is devastated.

When 91-year-old Washington VIP Viola Drath is found dead on her bathroom floor in her tony Georgetown townhouse, it appears she?s simply the victim of a nasty fall.

Young Alicia Kozakiewicz slips out one New Year's Eve to meet a new friend she's met on the Internet. But he's no friend.

Police are serving a bench warrant on local cashier Debra Sundstrom when they hear shots ring out inside the house. They find her shot dead upstairs - just as the entire house suddenly starts going up in flames.

Jesse Valencia is an openly gay student at the University of Missouri. When he's found with his throat slashed the question is whether this is a hate crime or whether one of his many lovers might have killed him.

Epifanio Medina is a neighborhood fixture in Passaic, NJ - a retiree who seems beloved by all. So when his body is discovered over 100 miles away in a New York State nature preserve, detectives are stumped.

Could picking the wrong doctor in your practice lead you towards a trail of death?

A mother walking with her children collapses in a Cincinnati Park, and is rushed to the hospital. But when her husband comes to fetch the kids, he tells police that one of them is missing. A massive hunt is launched for their 3-year-old foster child.

Robert Chambers became infamous as the 'Preppie Killer' a good-looking private school grad who murders a young lover in New York's Central Park.

All appears well in this upscale suburb of Detroit. But when a mother of two is bludgeoned to death and then stabbed repeatedly in her own garage, police and the community are shocked when the investigation leads close to home.

Ray Krone: A Phoenix postman and Air Force veteran wakes up one day to find policemen at his front door, accusing him of the murder of Kim Ancone. He's sentenced to death and spends years in prison trying to clear his name.

Ellen Robb: As the wife of an internationally renowned Ivy League professor, Rafael Robb, she's a highly unlikely crime victim. In fact, the only thing more unlikely about this case is the person who's ultimately convicted of killing her.

Dino Pantazes and his wife Clara do everything together. When Clara ends up dead, police try to find the culprit and end up looking close to home.

When a rape victim's eyewitness testimony helps put an innocent man in prison, he works to expose the real rapist from behind bars.

When John and Susan Sutton are shot in their Florida home, Susan is killed, and John survives, but he is blinded for life. Could this be the work of one of John's high-end legal clients?

In Longmont, CO, Tammy Tatum is brutally murdered right near her one-year-old daughter, Sadie. Now 24, Sadie reveals to Chris Hansen the shocking truth... that the killer was someone she knew her entire life.