Married couple Doug and Rozina Anderson's decision to take a long weekend in the peaceful woods of Northern California turns out to be a fateful mistake.

Three teenage boys looking for adventure in the peaceful and secluded high desert of California's Indian Creek run into a drifter with a mission to kill.

In 2007, 17-year old Katie is living in Tennessee with her doting parents. But Katie's been keeping secrets, and her parents are shocked to discover she's being stalked by an ex-boyfriend they didn't know existed.

By 1893, Chicago's World's Fair is in full swing. Dr. H.H. Holmes welcomes visitors to his hotel, a block-long structure designed to lure eager, young women into his clutches. Before long, he makes each mysteriously vanish, never to be seen again.

Dentist John Yelenic is thrilled when he meets the love of his life, Michelle. Ten years later, however, the veneer of their happy life crumbles when it's time to sign the divorce papers and police are called to the scene of a homicide.

Aurora, Indiana hadn't seen a murder in decades until Leigh Jennings was killed in her own home. Residents are horrified when the beloved mother and hairstylist is found dead. In a case where everyone liked the victim, anyone could be the killer.

In 1989, in peaceful Dryden, New York, a Christmastime massacre claims an entire family. Just when it seems the horror has passed, terror visits Dryden again. With these events, a so-called "curse" will descend on Dryden for ten years.

Six theories surrounding the Atlanta Child Murders are explored.

A young couple, The Stuarts, are robbed and shot in Boston. Carol and her unborn child are killed. Charles survives to describe their black assailant, inflaming racial tensions, until a surprise witness comes forward with a story that blows open the case.

When Long Island newlywed Lisa Solomon disappears on Christmas Eve, family and friends search for her relentlessly. Did she leave her husband of two months in the middle of the night? Or is there something more sinister at play?

After he clashes with co-workers, Tom Monfils mysteriously disappears on the job at a Green Bay paper mill. Soon enough it looks like murder, but no one is talking to detectives. Is it a conspiracy of silence, or a tragic miscarriage of justice?

Beautiful teenager Jennifer Levin is found strangled to death in Central Park. A prep school heartthrob, Robert Chambers, is arrested for the crime. The press seizes on his provocative claim that Jennifer’s death happened accidently during “rough sex.”

Thanks to a tipster, the police may finally find justice for Beverly Potts.

After a man commits suicide, police learn that he had stolen his identity.

A man walks out of a bank with $215,000 cash and promptly disappears.

A man is acquitted in the death of his wife in July of 1954.