Police respond to a call to find a deranged man has set his house on fire.

A Kansas town is left reeling after a family is found brutally murdered.

Terror grips Chicago after three bizarre and brutal murders go unsolved.

A boy's abduction becomes "The Crime of the Century" in 1920s Chicago.

A fun-loving 14-year-old vanishes after a family party in Cleveland.

A young man vanishes in Tumwater, WA, with no evidence of foul play.

While on a cruise, a young woman vanishes from her family's cabin.

A 9-year-old walks home from the local bowling alley but never arrives.

A transgender teen in Charlottesville, VA, goes missing.

Police suspect human trafficking when a young woman vanishes.

A mother of three never returns home after leaving work at a hospital.

A veteran and father of three disappears one night in Hermosa Beach, CA.

Sixteen-year-old Ali Lowitzer vanishes after getting off the school bus.

A 13-year-old vanishes while walking to her school bus stop in Nashville.

A popular fraternity brother suddenly goes missing, leaving a cryptic note.

A retired firefighter goes missing, and blood is found in his garage.