New York, NY, 1963. Two young women are brutally murdered in their Upper East Side apartment. If these girls aren’t safe, who is? The NYPD is under pressure to solve the high-profile case but make a tragic misstep while investigating.

West Palm Beach, FL, 1955. Esteemed Judge Curtis Chillingworth and his wife say goodbye to friends at a dinner party and are never seen again. Police unravel a tale of corruption and evil that leaves Florida in shock.

Denver, CO, 1955. United Airlines Flight 629 explodes in mid-air, killing everyone aboard. Crash investigators wonder if it was an accident at all. What follows is the discovery of the first-ever act of murder-by-airplane-bombing in the U.S.

Michigan, 1967-69. A series of young females from Michigan universities are murdered one by one. The young women of Southeastern Michigan are terrified and the police commence a massive hunt for the monster they call The Co-Ed Killer.

New York, NY, 1955. Ann and Billy Woodward are the darlings of New York society when tragedy strikes after a drunken dinner party. Billy lies in a pool of his own blood. Ann pulled the trigger by accident...or so she says.

Twenty-three year-old Brandi Wells is a spirited young woman about to get a second chance in pursuing her lifelong goal. But, her dreams are cut short when police find her abandoned vehicle the morning after she goes out alone to a nightclub.

A locally adored and respected mother of three living in Colorado vanishes. Her community is shocked to learn she has been working as an adult escort. With a violent previous marriage, and another marriage before that, no one knows whom to blame.

25-year-old Amy St. Laurent vanishes one night while out on a date with an out of town friend. Suspicion soon falls on a suspected sexual predator, but detectives need to work around the clock to find a way to connect him to the grisly crime.

Michele Whitaker is vivacious, attractive, and out of control. Drinking heavily and fighting with her mother, she hitches a ride to a truck stop and disappears. Most think she is dead, but her family never gives up.

Lee Cutler is the universally loved high school senior who disappears after dropping off his best friend on a cool autumn morning. The search involves police officers across two states, underwater divers, and a nationwide watch.

Maura Murray goes missing after her car swerves off a dark and windy road over 140 miles away from her dorm. As the years pass, her family and friends refuse to give up their search to discover what happened to her that fateful February night.

Billy Smolinski is a hard working tough guy who suddenly disappears a week after discovering that his girlfriend is cheating on him. Although police don't suspect the woman, clues point their investigation in the direction of her now dead son.

A college student disappears after leaving her son with a childhood friend. Her car is found abandoned a week later across state lines. Soon after, a warrant for her arrest is issued on felony theft charges. Could she be on the run?

As America's leading Atheist, Madalyn Murray O'Hair was also known as America's most hated woman. In 1995, when she inexplicably disappears along with two members of her family, and over a half-million dollars, rumors flew.

A Tampa Bay area realtor goes missing and investigators question her husband. Without evidence to make an arrest, investigators' case goes cold, while the husband leaves town with his girlfriend. Nine years later, the girlfriend helps solve the case.

John Spira is a beloved Chicago blues guitarist who disappears after leaving work one wintry evening. The intense search for the 45-year-old spans two years and commands the use of teams of investigators and state of the art equipment.